Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.57 |
| ▸ | EDNRB | P24530 | 5/20 | 0.57 |
| ▸ | DHPS | P49366 | 8/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061140 | 0.92 | EDNRA (0.67) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7851035 | 0.91 | EDNRA (0.48) | EDNRAEDNRBDHPS | |
| SCHEMBL4060083 | 0.90 | EDNRA (0.64) | EDNRAEDNRBDHPS | |
| SCHEMBL4062788 | 0.86 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL4059947 | 0.86 | EDNRA (0.61) | EDNRAEDNRBDHPS | |
| SCHEMBL7700301 | 0.85 | DHPS (0.64) | EDNRAEDNRBDHPS | |
| SCHEMBL4064948 | 0.85 | EDNRB (0.68) | EDNRAEDNRB | |
| SCHEMBL7699796 | 0.83 | EDNRA (0.52) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL5107961 | 0.83 | EDNRB (0.62) | EDNRAEDNRB | |
| SCHEMBL7853937 | 0.83 | DHPS (0.57) | EDNRAEDNRBDHPSABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083650-A1 | NOVEL SULFONYLAMINO-PYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-10-24 | — | — | WO | disclosed |