Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | DHPS | P49366 | 3/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | SGK1 | O00141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700545 | 0.88 | DHPS (0.42) | EDNRBEDNRADHPS | |
| SCHEMBL5654640 | 0.80 | EDNRA (0.51) | EDNRBEDNRADHPS | |
| SCHEMBL25234371 | 0.79 | EDNRA (0.50) | EDNRBEDNRADHPS | |
| SCHEMBL4064360 | 0.79 | DHPS (0.47) | EDNRBEDNRADHPSCSNK2A1 | |
| SCHEMBL7700001 | 0.78 | MYC (0.48) | DHPSSGK1 | |
| SCHEMBL6972287 | 0.76 | DHPS (0.42) | EDNRBEDNRADHPSCHEK2SGK1 | |
| SCHEMBL4060140 | 0.76 | DHPS (0.46) | EDNRBEDNRADHPS | |
| SCHEMBL5765220 | 0.75 | DHPS (0.40) | EDNRADHPS | |
| SCHEMBL5631564 | 0.74 | EDNRB (0.43) | EDNRBEDNRADHPS | |
| SCHEMBL5654649 | 0.73 | DHPS (0.62) | EDNRBEDNRADHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083650-A1 | NOVEL SULFONYLAMINO-PYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-10-24 | — | — | WO | disclosed |