SCHEMBL7700637

SCHEMBL7700637

C=C(C)C1CC=C(C)C(=O)C1C(=O)OCC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40
ALDH1A1 P00352 6/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
MAPT P10636 3/20 0.39
HSD17B10 Q99714 2/20 0.39
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
TGFBR1 P36897 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.36
POLB P06746 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
TP53 P04637 1/20 0.34
HTT P42858 2/20 0.34
NFE2L2 Q16236 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8330697 0.87 ALDH1A1 (0.41) TSHRALOX15MAPK1ALDH1A1MEN1
SCHEMBL30597491 0.74 MEN1 (0.49) TSHRALOX15ALDH1A1MEN1KMT2A
SCHEMBL21673038 0.73 MEN1 (0.47) TSHRALOX15MAPK1ALDH1A1MEN1
SCHEMBL5683303 0.73 MEN1 (0.47) TSHRALOX15ALDH1A1MEN1KMT2A
SCHEMBL7666958 0.73 MEN1 (0.47) TSHRALOX15ALDH1A1MEN1KMT2A
SCHEMBL1244477 0.73 MEN1 (0.47) TSHRALOX15MAPK1ALDH1A1MEN1
SCHEMBL1196232 0.71 ALDH1A1 (0.40) TSHRALDH1A1MEN1KMT2AMAPT
SCHEMBL20969493 0.70 ALDH1A1 (0.39) TSHRALDH1A1MEN1KMT2ATGFBR1
SCHEMBL20969489 0.70 ALDH1A1 (0.39) TSHRALDH1A1MEN1KMT2ATGFBR1
SCHEMBL20969207 0.68 MEN1 (0.40) ALDH1A1MEN1KMT2ATGFBR1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6348618-B1 PREPARING ORGANOLEPTIC OR ANTIMICROBIAL COMPOUNDS BY CONTACTING BETA-KETO ESTER WITH MATERIAL SELECTED FROM BACTERIA, ENZYMES, AND MATERIAL HAVING ACIDIC OR ALKALINE PH, ELEVATING TEMPERATURE, EXPOSING TO LIGHT GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2002-02-19 US disclosed
US-6222062-B1 USEFUL AS PRECURSORS FOR ORGANOLEPTIC COMPOUNDS, ESPECIALLY FOR FLAVORS, FRAGRANCES AND MASKING AGENTS AND ANTIMICROBIAL COMPOUNDS GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2001-04-24 US disclosed
EP-1090624-A2 Beta ketoester Givaudan SA (CH) 2001-04-11 EP disclosed