SCHEMBL1244477

SCHEMBL1244477

C=C(C)C1CC=C(C)C(=O)C1O

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
ALDH1A1 P00352 1/20 0.47
TGFBR1 P36897 1/20 0.44
TSHR P16473 3/20 0.37
TP53 P04637 1/20 0.37
NFE2L2 Q16236 1/20 0.36
LMNA P02545 2/20 0.34
ALOX15 P16050 1/20 0.32
EPHX2 P34913 1/20 0.31
TRPA1 O75762 1/20 0.31
MAPT P10636 1/20 0.30
MAPK1 P28482 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21673038 1.00 MEN1 (0.47) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL30597491 0.83 MEN1 (0.49) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL7666958 0.81 MEN1 (0.47) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL5683303 0.81 MEN1 (0.47) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL8330697 0.74 ALDH1A1 (0.41) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL7700637 0.73 TSHR (0.40) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL20969207 0.73 MEN1 (0.40) MEN1KMT2AALDH1A1TGFBR1NFE2L2
SCHEMBL20969489 0.72 ALDH1A1 (0.39) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL20969493 0.72 ALDH1A1 (0.39) MEN1KMT2AALDH1A1TGFBR1TSHR
SCHEMBL24780080 0.69 TSHR (0.47) MEN1KMT2AALDH1A1TGFBR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8592621-B2 Precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease SYMRISE AG (DE) 2013-11-26 US claimed
US-20110045069-A1 PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE SYMRISE GMBH CO. KG (DE) 2011-02-24 US claimed
US-20240108040-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2024-04-04 US disclosed
US-11758933-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2023-09-19 US disclosed
EP-3368542-B1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2022-06-22 EP disclosed
US-11357246-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2022-06-14 US disclosed
US-20210227863-A1 HIGH INTENSITY SWEETENERS SENOMYX, INC. 2021-07-29 US disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 EP disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 US disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 US disclosed
US-20170143022-A1 Compositions Incorporating an Umami Flavor Agent SENOMYX INC (US) 2017-05-25 US disclosed
WO-2017075257-A2 HIGH INTENSITY SWEETENERS SENOMYX, INC. (US) 2017-05-04 WO disclosed
US-20170119032-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED 2017-05-04 US disclosed
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2017-04-06 US disclosed
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION SENOMYX INC (US) 2017-03-30 US disclosed
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF SENOMYX INC (US) 2016-12-29 US disclosed
CN-104105730-B Method for producing cured coating film, optical film, and method for producing thin film molded body DIC株式会社 2016-08-24 CN disclosed
US-8592621-B2 Precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease SYMRISE AG (DE) 2013-11-26 US disclosed
US-20110045069-A1 PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE SYMRISE GMBH CO. KG (DE) 2011-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240108040-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 MEN1 2644/4885KMT2A 2697/4885ALDH1A1 978/4885
US-20170119032-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 MEN1 2644/4885KMT2A 2697/4885ALDH1A1 978/4885
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF TAS2R5, TAS1R1, TAS2R1 MEN1 3045/4885KMT2A 2214/4885ALDH1A1 1490/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 MEN1 1052/4885KMT2A 3630/4885ALDH1A1 3726/4885
US-11357246-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 MEN1 2644/4885KMT2A 2697/4885ALDH1A1 978/4885
US-20170143022-A1 Compositions Incorporating an Umami Flavor Agent TAS2R8, TAS2R45, TAS2R40 MEN1 2743/4885KMT2A 2393/4885ALDH1A1 263/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 MEN1 1247/4885KMT2A 4178/4885ALDH1A1 3880/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 MEN1 1247/4885KMT2A 4178/4885ALDH1A1 3880/4885
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION TRPA1, PDE6G, PDE6D MEN1 404/4885KMT2A 4022/4885ALDH1A1 1029/4885
US-20210227863-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 MEN1 2644/4885KMT2A 2697/4885ALDH1A1 978/4885
US-11758933-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 MEN1 2644/4885KMT2A 2697/4885ALDH1A1 978/4885
US-20110045069-A1 PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE TAS1R2, TAS2R5, TAS2R1 MEN1 1488/4885KMT2A 2910/4885ALDH1A1 3134/4885
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 MEN1 1247/4885KMT2A 4178/4885ALDH1A1 3880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.