Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21537944 | 0.75 | BACE1 (0.62) | PGROPRM1OPRK1OPRL1PDE7A | |
| SCHEMBL1223213 | 0.75 | BACE1 (0.62) | PGROPRM1OPRK1OPRL1PDE7A | |
| SCHEMBL29799132 | 0.75 | BACE1 (0.62) | PGROPRM1OPRK1OPRL1PDE7A | |
| SCHEMBL1268479 | 0.73 | BACE1 (0.64) | PGROPRM1OPRK1OPRL1PDE7A | |
| SCHEMBL29387092 | 0.73 | BACE1 (0.64) | PGROPRM1OPRK1OPRL1PDE7A | |
| SCHEMBL4305578 | 0.72 | LMNA (0.35) | — | |
| SCHEMBL750088 | 0.72 | PDK2 (0.55) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL971170 | 0.71 | ESR1 (0.33) | — | |
| SCHEMBL973291 | 0.71 | ESR1 (0.33) | — | |
| SCHEMBL12598497 | 0.70 | PGR (0.56) | PGRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173212-A1 | CONTRACEPTIVE COMPOSITIONS CONTANING INDOLONE DERIVATIVES AND PROGESTATIONAL AGENTS | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066167-A1 | CONTRACEPTIVE COMPOSITIONS CONTAINING INDOLINE DERIVATIVES AND PROGESTATIONAL AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |