Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | PRCP | P42785 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703888 | 0.88 | PRCP (0.39) | TRPM8PRCPHDAC8 | |
| SCHEMBL7698116 | 0.86 | TRPM8 (0.45) | CYP19A1CYP11B2TRPM8PRCPHDAC8 | |
| SCHEMBL7701133 | 0.86 | PRCP (0.54) | PRCPHDAC8 | |
| SCHEMBL7699769 | 0.86 | PRCP (0.37) | TRPM8PRCPHDAC8 | |
| SCHEMBL7702996 | 0.84 | TRPM8 (0.39) | TRPM8PRCPHDAC8 | |
| SCHEMBL7705666 | 0.82 | GAA (0.36) | CYP19A1CYP11B2TRPM8PRCPKDM4E | |
| SCHEMBL7701032 | 0.81 | HPGD (0.37) | TRPM8PRCPHPGD | |
| SCHEMBL7700015 | 0.81 | TRPM8 (0.39) | TRPM8PRCPHDAC8 | |
| SCHEMBL7704881 | 0.79 | CYP19A1 (0.44) | CYP19A1MAPTHPGDKDM4ECYP3A4 | |
| SCHEMBL7704956 | 0.79 | CHRM3 (0.47) | PRCPHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |