SCHEMBL770117

SCHEMBL770117

Nc1nc(=O)n([C@@H]2O[C@H](CO)C(O)C2O)cc1Cl

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.62
MTOR P42345 2/20 0.62
ALDH1A1 P00352 2/20 0.62
THRB P10828 1/20 0.62
MDM2 Q00987 1/20 0.62
NCOA1 Q15788 1/20 0.62
NCOA3 Q9Y6Q9 1/20 0.62
GMNN O75496 1/20 0.62
TP53 P04637 1/20 0.62
NFKB1 P19838 1/20 0.62
DNMT1 P26358 1/20 0.62
THPO P40225 1/20 0.62
HTT P42858 1/20 0.62
RAB9A P51151 1/20 0.62
BLM P54132 1/20 0.62
HBB P68871 1/20 0.62
PMP22 Q01453 1/20 0.62
PYGM P11217 1/20 0.57
MAPT P10636 1/20 0.52
CDA P32320 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL770116 1.00 LMNA (0.62) LMNAMTORALDH1A1THRBMDM2
SCHEMBL2577234 1.00 LMNA (0.62) LMNAMTORALDH1A1THRBMDM2
SCHEMBL10341279 0.90 LMNA (0.50) LMNAMTORALDH1A1THRBMDM2
SCHEMBL11209925 0.90 LMNA (0.50) LMNAMTORALDH1A1THRBMDM2
SCHEMBL10341278 0.90 LMNA (0.50) LMNAMTORALDH1A1THRBMDM2
SCHEMBL10341280 0.90 LMNA (0.50) LMNAMTORALDH1A1THRBMDM2
Hydrochloric Acid SCHEMBL10888552 0.89 LMNA (0.49) LMNAMTORALDH1A1THRBMDM2
SCHEMBL2582673 0.89 LMNA (0.49) LMNAMTORALDH1A1THRBMDM2
SCHEMBL6716527 0.89 PDE2A (0.55) LMNAMTORALDH1A1THRBMDM2
SCHEMBL6716522 0.89 PDE2A (0.55) LMNAMTORALDH1A1THRBMDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12357664-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2025-07-15 US claimed
EP-4023233-A2 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2022-07-06 EP claimed
US-20220088097-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2022-03-24 US claimed
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-06-01 US claimed
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-07-30 US claimed
WO-2019195494-A1 COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-10 WO claimed
EP-3518947-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2019-08-07 EP claimed
WO-2018064134-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2018-04-05 WO claimed
US-20180085411-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2018-03-29 US claimed
EP-3186387-A1 METHOD OF DETERMINING THE ACTIVITY OF ENZYMES CONVERTING CYTOSINE DERIVATIVES TO URACIL DERIVATIVES IN CELLS, TISSUES AND ORGANISMS Univerzita Palackého v Olomouci (CZ) 2017-07-05 EP claimed
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-08-25 US claimed
US-6887707-B2 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-05-03 US claimed
EP-0653439-B1 Stabilized oligonucleotids and the use thereof AVENTIS PHARMA GMBH (DE) 2004-04-28 EP claimed
US-20040059104-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2004-03-25 US claimed
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2003-06-26 US claimed
US-6063628-A Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2000-05-16 US claimed
US-6020483-A Nucleoside modifications by palladium catalyzed methods NEXSTAR PHARMACEUTICALS, INC. (US) 2000-02-01 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed
EP-0653439-A2 Stabilized oligonucleotids and the use thereof HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-17 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules PIK3CA, CHAMP1, TYMP LMNA 1794/4885MTOR 131/4885ALDH1A1 4371/4885
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD LMNA 3576/4885MTOR 2746/4885ALDH1A1 1365/4885
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules PIK3CA, CHAMP1, TYMP LMNA 1794/4885MTOR 131/4885ALDH1A1 4371/4885
US-20040059104-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP LMNA 3677/4885MTOR 531/4885ALDH1A1 2112/4885
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD LMNA 3576/4885MTOR 2746/4885ALDH1A1 1365/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.