Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187119 | 0.86 | OPRL1 (0.44) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL7706497 | 0.84 | OPRL1 (0.54) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL7701290 | 0.83 | LMNA (0.50) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL16876761 | 0.82 | OPRL1 (0.43) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL7703855 | 0.81 | MCHR1 (0.47) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL16876851 | 0.80 | RORC (0.42) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL16876815 | 0.80 | EEF2K (0.42) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL7706380 | 0.80 | DRD4 (0.50) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL16876782 | 0.79 | CHRNA7 (0.47) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL5556020 | 0.79 | DRD2 (0.47) | OPRL1OPRM1OPRD1OPRK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921125-B1 | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | disclosed |
| US-6043366-A | USEFUL IN TREATING DISORDERS INVOLVING THE ORPHANIN FQ(A SEVENTEEN AMINO ACID LONG PEPTIDE) RECEPTOR. | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0921125-A1 | 1,3,8-Triaza-spiro 4,5 decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |