Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB7A | P51149 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582515 | 0.94 | HPGD (0.37) | HPGDRAB7ARAB9ASMN1; SMN2MAPT | |
| SCHEMBL7575384 | 0.92 | POLB (0.36) | HPGDRAB7ARAB9ASMN1; SMN2MAPT | |
| SCHEMBL7699460 | 0.87 | NPC1 (0.48) | HPGDRAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL7698367 | 0.86 | KDM4E (0.50) | HPGDRAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL7699527 | 0.86 | KDM4E (0.50) | HPGDRAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL7700382 | 0.86 | ALDH1A1 (0.37) | HPGDRAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL7580060 | 0.84 | HDAC1 (0.38) | HPGDMAPTPOLBLMNAMEN1 | |
| SCHEMBL7564276 | 0.81 | CYP1A2 (0.39) | HPGDRAB7ALMNAMEN1KMT2A | |
| SCHEMBL7519532 | 0.81 | PTPN1 (0.47) | HPGDRAB7ARAB9ASMN1; SMN2MAPT | |
| SCHEMBL5844070 | 0.79 | HPGD (0.39) | HPGDRAB9ASMN1; SMN2POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002004458-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-17 | — | — | WO | disclosed |