Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 1/20 | 0.52 |
| ▸ | GNB1 | P62873 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422283 | 0.83 | KDM4E (0.48) | CYP1A2CYP3A4CYP2C19PARP1KDM4E | |
| SCHEMBL7428454 | 0.82 | KDM4E (0.47) | CYP1A2CYP3A4CYP2C19PARP1KDM4E | |
| SCHEMBL10187520 | 0.81 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7481793 | 0.81 | ALDH1A1 (0.47) | CYP1A2CYP3A4CYP2C19PARP1KDM4E | |
| SCHEMBL10187518 | 0.80 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7428940 | 0.80 | FHIT (0.46) | CYP1A2CYP3A4CYP2C19KMT2ANFKB1 | |
| SCHEMBL7561730 | 0.80 | KDM4E (0.46) | CYP1A2CYP3A4CYP2C19PARP1KDM4E | |
| SCHEMBL10187519 | 0.80 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL204756 | 0.80 | PTPN1 (0.50) | GNG2GNB1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10187517 | 0.78 | KDM4E (0.39) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350885-B1 | TREATMENT OF MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURYSM, HEART FAILURE, LEFT VENTRICULAR DILATION, RESTENOSIS, PERIODONTAL DISEASE, CORNEAL ULCERATION, TREATMENT OF BURNS, DECUBITAL ULCERS, WOUND HEALING AGENT | WARNER-LAMBERT COMPANY | 2002-02-26 | — | — | US | disclosed |