Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704389 | 0.77 | — | — | |
| SCHEMBL7704780 | 0.76 | CYP4F2 (0.31) | — | |
| SCHEMBL7704790 | 0.71 | ALDH1A1 (0.38) | TSHRHIF1AFFAR1CPT2TDP1 | |
| SCHEMBL27785813 | 0.69 | TSHR (0.46) | TSHRHIF1AFFAR1CPT2TDP1 | |
| SCHEMBL27509626 | 0.69 | — | — | |
| SCHEMBL16600187 | 0.69 | — | — | |
| SCHEMBL1785190 | 0.68 | TSHR (0.48) | TSHRHIF1AFFAR1CPT2TDP1 | |
| Glutaral SCHEMBL29229225 | 0.66 | HIF1A (0.62) | TSHRHIF1ATDP1 | |
| SCHEMBL1783206 | 0.66 | TSHR (0.59) | TSHRHIF1AFFAR1CPT2TDP1 | |
| SCHEMBL1784663 | 0.66 | TSHR (0.52) | TSHRHIF1AFFAR1CPT2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056716-B1 | CYCLOHEXANEDIOLE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-12-11 | — | — | EP | disclosed |
| US-6184422-B1 | TREATMENT AND PREVENTION OF HYPERPROLIFERATIVE SKIN DISEASES; REVERSING CONDITIONS ASSOCIATED WITH PHOTODAMAGE; ANTITUMOR, -CARCINOGENIC AGENTS; PSORIASIS; DISORDERS OF NEOPLASTIC DISEASES; KERATINIZATION/KERATOSIS; ACNE; SEBORRHEA | HOFFMAN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-1056716-A1 | CYCLOHEXANEDIOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043646-A1 | CYCLOHEXANEDIOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-02 | — | — | WO | disclosed |