Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 7/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 3/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.31 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563819 | 0.85 | FNTA (0.38) | — | |
| SCHEMBL7567659 | 0.82 | KDM5A (0.35) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL8194981 | 0.81 | CTSA (0.35) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL7864451 | 0.81 | CTSA (0.35) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL8199727 | 0.80 | CTSA (0.36) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL8197703 | 0.76 | FFAR4 (0.34) | CTSAADORA2BADORA1PPARGPPARD | |
| SCHEMBL7570258 | 0.75 | CYP11B1 (0.34) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL7610663 | 0.75 | BRS3 (0.35) | CTSAADORA2BADORA1KDM5AKDM5B | |
| SCHEMBL8186055 | 0.75 | ADORA2B (0.35) | CTSAADORA2BADORA1PPARGPPARD | |
| SCHEMBL7569513 | 0.75 | TP53 (0.33) | CTSAADORA2BADORA1KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342765-B1 | COMPOUNDS THAT INHIBIT FARNESYLATION OF MUTANT RAS GENE PRODUCTS; TREATING DISEASES, ESPECIALLY CANCER, WHICH ARE MEDIATED THROUGH FARNESYLATION OF RAS | ASTRAZENECA UK LIMITED (GB) | 2002-01-29 | — | — | US | disclosed |