Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 9/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 4/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185548 | 0.92 | CTSA (0.36) | CTSAF2RL1ADORA2BADORA1FFAR4 | |
| SCHEMBL8185964 | 0.87 | F2RL1 (0.36) | F2RL1KDM5AKDM4CKDM5B | |
| SCHEMBL8192871 | 0.84 | FNTA (0.39) | — | |
| SCHEMBL8185513 | 0.84 | ITGB3 (0.33) | CTSAADORA2BADORA1 | |
| SCHEMBL8194981 | 0.82 | CTSA (0.35) | CTSAMRGPRX4ADORA2BADORA1KDM5A | |
| SCHEMBL7864451 | 0.81 | CTSA (0.35) | CTSAMRGPRX4ADORA2BADORA1KDM5A | |
| SCHEMBL7701993 | 0.80 | CTSA (0.33) | CTSAMRGPRX4ADORA2BADORA1KDM5A | |
| SCHEMBL8197703 | 0.80 | FFAR4 (0.34) | CTSAADORA2BADORA1FFAR4HPGD | |
| SCHEMBL8185758 | 0.76 | CTSA (0.40) | CTSAF2RL1 | |
| SCHEMBL8186055 | 0.76 | ADORA2B (0.35) | CTSAADORA2BADORA1FFAR4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020611-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |