Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621648 | 0.84 | KDM4E (0.89) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL6329236 | 0.83 | KDM4E (0.76) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL4094165 | 0.80 | KDM4E (0.76) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL17367227 | 0.80 | KDM4E (0.93) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL4142958 | 0.79 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| Lithium SCHEMBL30669498 | 0.78 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL6329154 | 0.77 | ALDH1A1 (0.61) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL28022669 | 0.75 | HSD17B10 (0.78) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL29130443 | 0.75 | KDM4E (0.71) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL29130442 | 0.73 | HPGD (0.64) | KDM4EHSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358959-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |
| WO-2000043374-A1 | POLYAZANAPHTHALENONE DERIVATIVES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |