Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11528893 | 0.88 | CYP2D6 (0.60) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL27906416 | 0.85 | HDAC3 (0.46) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL7707787 | 0.84 | SLC6A2 (0.41) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL4280331 | 0.83 | SLC22A6 (0.43) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL29237760 | 0.82 | SLC6A2 (0.39) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL7705158 | 0.80 | TSHR (0.52) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL8006389 | 0.80 | GPR84 (0.39) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL27375200 | 0.80 | CYP2D6 (0.52) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL27801322 | 0.79 | SLC6A2 (0.42) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| SCHEMBL27906400 | 0.78 | TSHR (0.42) | SLC6A2SLC6A4BLMSLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-14 | — | — | US | disclosed |
| US-9650384-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-05-16 | — | — | US | disclosed |
| US-9650384-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-05-16 | — | — | US | disclosed |
| WO-2016022881-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-02-11 | — | — | WO | disclosed |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-02-11 | — | — | US | disclosed |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-02-11 | — | — | US | disclosed |
| US-8946468-B2 | Process for producing ester compound having an internal unsaturated bond or cyclic olefin | JX NIPPON OIL & ENERGY CORPORATION (JP) | 2015-02-03 | — | — | US | disclosed |
| US-20120316360-A1 | PROCESS FOR PRODUCING ESTER COMPOUND HAVING a,ß-UNSATURATED BOND | OSAKA UNIVERSITY (JP) | 2012-12-13 | — | — | US | disclosed |
| US-6348623-B2 | (CO)POLYMERS OF 1-ACETOXY-2-METHOXY-3-BUTENE FOR EXAMPLE; CAN COPOLYMERIZE WITH VINYL ACETATE; REACTING ACETOACETOXY FUNCTIONAL POLYMER WITH AMMONIA OR PRIMARY OR SECONDARY AMINES TO FORM ENAMINE FUNCTIONAL POLYMERS; COATINGS | EASTMAN CHEMICAL COMPANY | 2002-02-19 | — | — | US | disclosed |
| US-20010051690-A1 | Polymers of 3-butene esters, their preparation and use | EASTMAN CHEMICAL COMPANY | 2001-12-13 | — | — | US | disclosed |
| US-6228949-B1 | ACETOACETOXY-DERIVATIZED HOMO OR CO-POLY(3,4-EPOXY-1-BUTENE) WHEREBY THE ACETOACETOXY GROUPS HAVE BEEN REACTED WITH AMMONIA, PRIMARY OR SECONDARY AMINE TO FORM ENAMINE FUNCTIONAL GROUPS; HIGH MOLECULAR WEIGHT COATINGS, ADHESIVES | EASTMAN CHEMICAL COMPANY | 2001-05-08 | — | — | US | disclosed |
| US-6160057-A | Polymers of 3-butene esters, their preparation and use | EASTMAN CHEMICAL COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| US-6121400-A | FREE-RADICAL POLYMERIZATION PRODUCT; FOR COATING COMPOSITIONS SUCH AS INKS, ADHESIVES, PAINTS, AND FILMS | EASTMAN CHEMICAL COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| US-6121399-A | Polymers of 3-butene esters, their preparation and use | EASTMAN CHEMICAL COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| EP-1023340-A1 | POLYMERS OF 3-BUTENE ESTERS, THEIR PREPARATION AND USE | EASTMAN CHEMICAL COMPANY (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020666-A1 | POLYMERS OF 3-BUTENE ESTERS, THEIR PREPARATION AND USE | EASTMAN CHEMICAL COMPANY (US) | 1999-04-29 | — | — | WO | disclosed |
| US-4734100-A | Process for printing or dyeing cellulose-containing textile material | CIBA-GEIGY CORPORATION (US) | 1988-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DHFR, FOLR1, DPYD | SLC6A2 2626/4885SLC6A4 1046/4885BLM 2645/4885 |
| US-20120316360-A1 | PROCESS FOR PRODUCING ESTER COMPOUND HAVING a,ß-UNSATURATED BOND | COASY, OXER1, ACSL1 | SLC6A2 4763/4885SLC6A4 4832/4885BLM 4594/4885 |
| US-20010051690-A1 | Polymers of 3-butene esters, their preparation and use | CCNT1, C1S, H1-3 | SLC6A2 3999/4885SLC6A4 4554/4885BLM 3723/4885 |
| US-20160039830-A1 | Substituted Pyrimidine Compounds and Methods of Use and Manufacture | DHFR, FOLR1, DPYD | SLC6A2 2626/4885SLC6A4 1046/4885BLM 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.