Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509076 | 0.83 | MAPT (0.46) | KMT2AALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL3676305 | 0.79 | ADORA2A (0.54) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29343294 | 0.77 | GRM4 (0.43) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7699707 | 0.77 | ADORA2A (0.51) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7703870 | 0.76 | ADORA2A (0.50) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7699929 | 0.75 | TSHR (0.47) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL19615361 | 0.74 | MEN1 (0.48) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL21570271 | 0.73 | SMN1; SMN2 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18395181 | 0.73 | ALOX15 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL7700988 | 0.72 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |