Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210279 | 0.83 | HTT (0.43) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15651814 | 0.82 | CXCR4 (0.42) | LMNASMN1; SMN2KDM4E | |
| SCHEMBL19635510 | 0.80 | POLB (0.47) | ALDH1A1LMNASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL973113 | 0.78 | LMNA (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL7699075 | 0.77 | LMNA (0.49) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL19635528 | 0.76 | POLB (0.47) | ALDH1A1LMNASMN1; SMN2KDM4EPOLB | |
| SCHEMBL859 | 0.76 | POLB (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL5900613 | 0.76 | LMNA (0.48) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL1810598 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRLMNAMAPTSMN1; SMN2 | |
| SCHEMBL7703155 | 0.74 | LMNA (0.47) | LMNAMAPTSMN1; SMN2RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2530078-A1 | THIAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |