Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HHAT | Q5VTY9 | 3/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702539 | 0.77 | PRCP (0.46) | PRCPHHATCYP2D6HDAC8 | |
| SCHEMBL7701133 | 0.76 | PRCP (0.54) | PRCPHHATCYP2D6HDAC8 | |
| SCHEMBL7699760 | 0.75 | PRCP (0.36) | PRCPDRD1HHATADRA1DADRA1A | |
| SCHEMBL7702996 | 0.75 | TRPM8 (0.39) | PRCPHHATCYP2D6HDAC8 | |
| SCHEMBL7698116 | 0.75 | TRPM8 (0.45) | PRCPHHATCYP2D6HDAC8 | |
| SCHEMBL7703410 | 0.74 | PRCP (0.35) | PRCPDRD1HHATADRA1DADRA1A | |
| SCHEMBL7706720 | 0.74 | PRCP (0.38) | PRCPDRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7706788 | 0.74 | CD44 (0.40) | PRCPDRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7703888 | 0.74 | PRCP (0.39) | PRCPHHATADRA1DADRA1AADRA1B | |
| SCHEMBL7705532 | 0.74 | HHAT (0.37) | PRCPHHATADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |