Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705677 | 0.85 | HHAT (0.37) | PRCPTRPM8ADRA1DADRA1AADRA1B | |
| SCHEMBL7705532 | 0.85 | HHAT (0.37) | PRCPTRPM8ADRA1DADRA1AADRA1B | |
| SCHEMBL7705666 | 0.80 | GAA (0.36) | PRCPTRPM8ADRA1DADRA1AADRA1B | |
| SCHEMBL7705731 | 0.80 | TRPM8 (0.36) | PRCPTRPM8ADRA1DADRA1AADRA1B | |
| SCHEMBL7698116 | 0.79 | TRPM8 (0.45) | PRCPTRPM8HDAC8CYP11B2HHAT | |
| SCHEMBL7705909 | 0.79 | CYP19A1 (0.44) | PRCPTRPM8HDAC8CYP11B2 | |
| SCHEMBL7699769 | 0.79 | PRCP (0.37) | PRCPTRPM8ADRA1DADRA1AADRA1B | |
| SCHEMBL7701133 | 0.78 | PRCP (0.54) | PRCPHDAC8HHAT | |
| SCHEMBL7698083 | 0.78 | FNTA (0.34) | PRCP | |
| SCHEMBL7705565 | 0.77 | CHRM3 (0.35) | PRCPADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |