Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708407 | 0.89 | ADORA2A (0.53) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7487041 | 0.88 | ADORA2A (0.51) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7703126 | 0.86 | ADORA2A (0.53) | NPC1RAB9AMAPTSMN1; SMN2ADORA2A | |
| SCHEMBL7486137 | 0.84 | ADORA2A (0.54) | ADORA2A | |
| SCHEMBL7703244 | 0.82 | DPP4 (0.47) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7708864 | 0.82 | TDO2 (0.41) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7703024 | 0.81 | ADORA2A (0.49) | ADORA2AALDH1A1 | |
| SCHEMBL7705607 | 0.81 | NPC1 (0.52) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7705869 | 0.80 | ADORA2A (0.56) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7711821 | 0.78 | ADORA2A (0.54) | MAPTSMN1; SMN2MEN1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |