Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701328 | 0.88 | TDP1 (0.48) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL7698688 | 0.86 | HDAC3 (0.51) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL7698636 | 0.86 | HPGD (0.48) | POLBKMT2AMAPTCYP1A2MEN1 | |
| SCHEMBL30229280 | 0.84 | HDAC3 (0.52) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL9558860 | 0.82 | MAPT (0.49) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL7745895 | 0.81 | MAPT (0.45) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL9558402 | 0.79 | MAPT (0.50) | POLBKMT2AMAPTCYP1A2CYP2C9 | |
| SCHEMBL8309680 | 0.78 | HPN (0.49) | POLBKMT2AMAPTALOX15GAA | |
| SCHEMBL8335793 | 0.76 | GAA (0.57) | POLBKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL8337417 | 0.75 | GAA (0.49) | POLBKMT2AMAPTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420428-B1 | TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-07-16 | — | — | US | claimed |
| US-5225444-A | Antiinflammatory agents or antiallergens | G. D. SEARLE & CO. (US) | 1993-07-06 | — | — | US | claimed |
| EP-0190682-B1 | NOVEL DISUBSTITUTED 4-HYDROXYPHENYLTHIO ANILIDES | G.D. Searle & Co. (US) | 1990-09-12 | — | — | EP | claimed |
| EP-0190682-A2 | Novel disubstituted 4-hydroxyphenylthio anilides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | claimed |
| US-6420428-B1 | TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-07-16 | — | — | US | disclosed |
| US-6369097-B1 | Treatment and prevention of hepatic disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-04-09 | — | — | US | disclosed |
| US-6348493-B1 | TREATMENT OF HEPATITIS C BY ADMINISTERING 2,6-DI-TER-BUTYLPHENOL | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-19 | — | — | US | disclosed |
| US-6218437-B1 | ADMINISTERING A THERAPEUTIC AMOUNT OF DI-TERT-BUTYLPHENOL DERIVATIVE TO SUBJECT UNDER CONDITIONS SUCH THAT SAID SYMPTOMS ARE DIMINISHED | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-04-17 | — | — | US | disclosed |
| WO-2001021166-A1 | TREATMENT AND PREVENTION OF HEPATIC DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-03-29 | — | — | WO | disclosed |
| US-5225444-A | Antiinflammatory agents or antiallergens | G. D. SEARLE & CO. (US) | 1993-07-06 | — | — | US | disclosed |
| US-5071876-A | Antiinflammatory agent; antiallergen; skin disorders; asthma; enzyme inhibitors of 5-lipogenase | G. D. SEARLE & CO. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0190682-B1 | NOVEL DISUBSTITUTED 4-HYDROXYPHENYLTHIO ANILIDES | G.D. Searle & Co. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0190682-A2 | Novel disubstituted 4-hydroxyphenylthio anilides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |