Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515843 | 0.88 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2GLAPKM | |
| SCHEMBL7542531 | 0.87 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2GLAPKM | |
| SCHEMBL7699895 | 0.77 | KMT2A (0.42) | KDM4EALDH1A1KMT2AMAPTHPGD | |
| SCHEMBL7701621 | 0.77 | HDAC1 (0.36) | KDM4EALDH1A1GLAKMT2AHPGD | |
| SCHEMBL7694698 | 0.76 | BCHE (0.40) | KDM4EALDH1A1SMN1; SMN2TP53KMT2A | |
| SCHEMBL7555860 | 0.75 | AKR1C2 (0.37) | KDM4EGAAKMT2APOLBLMNA | |
| SCHEMBL7542021 | 0.75 | PTPN1 (0.38) | GAAKMT2A | |
| SCHEMBL5837637 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2GLAPKM | |
| SCHEMBL7571116 | 0.73 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL7702006 | 0.70 | KDM4E (0.46) | KDM4EALDH1A1KMT2AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002004458-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-17 | — | — | WO | claimed |
| WO-2002004458-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-17 | — | — | WO | disclosed |