Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837745 | 0.87 | PTPN1 (0.44) | AKR1C2PTPN5MTNR1AMTNR1BKDM4E | |
| SCHEMBL7550192 | 0.84 | AKR1C2 (0.38) | AKR1C2PTPN5MTNR1AMTNR1BKDM4E | |
| SCHEMBL7699895 | 0.82 | KMT2A (0.42) | MTNR1AMTNR1BKDM4EMEN1KMT2A | |
| SCHEMBL7702706 | 0.80 | KDM4E (0.41) | KDM4ELMNAMEN1KMT2ACYP2C9 | |
| SCHEMBL5838311 | 0.80 | AKR1C2 (0.39) | AKR1C2PTPN5MTNR1AMTNR1BKDM4E | |
| SCHEMBL5837754 | 0.79 | AKR1C2 (0.36) | AKR1C2PTPN5MTNR1AMTNR1BKDM4E | |
| SCHEMBL7701621 | 0.77 | HDAC1 (0.36) | KDM4ELMNAKMT2ACYP2C9CYP2C19 | |
| SCHEMBL7542021 | 0.77 | PTPN1 (0.38) | GAAMEN1KMT2A | |
| SCHEMBL7694698 | 0.77 | BCHE (0.40) | KDM4ELMNAPOLBMEN1KMT2A | |
| SCHEMBL7571116 | 0.76 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |