Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.74 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7706037 | 0.94 | SLC6A9 (0.69) | SLC6A9PPARDHSD17B2CA1CA2 | |
| Org-25935 SCHEMBL7704305 | 0.94 | SLC6A9 (0.85) | SLC6A9PPARDCA1CA2CA7 | |
| Org-25935 SCHEMBL7703028 | 0.94 | SLC6A9 (0.85) | SLC6A9PPARDCA1CA2CA7 | |
| Lithium Ion SCHEMBL7706192 | 0.90 | SLC6A9 (0.64) | SLC6A9PPARDHSD17B2CA1CA2 | |
| Lithium Ion SCHEMBL7706983 | 0.86 | SLC6A9 (0.71) | SLC6A9TAS2R14MTNR1A | |
| Lithium Ion SCHEMBL7704515 | 0.85 | SLC6A9 (0.60) | SLC6A9PPARDHSD17B2CA1CA2 | |
| Org-25935 SCHEMBL1761267 | 0.85 | SLC6A9 (1.00) | SLC6A9PPARDCA1CA2CA7 | |
| Org-25935 SCHEMBL27034881 | 0.85 | SLC6A9 (1.00) | SLC6A9PPARDCA1CA2CA7 | |
| Org-25935 SCHEMBL7703430 | 0.85 | SLC6A9 (1.00) | SLC6A9PPARDCA1CA2CA7 | |
| Lithium Ion SCHEMBL7700187 | 0.85 | SLC6A9 (0.70) | SLC6A9PPARDMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |