Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7706037 | 0.91 | SLC6A9 (0.69) | SLC6A9HSD17B2CA1CA2CA9 | |
| Lithium Ion SCHEMBL7703313 | 0.90 | SLC6A9 (0.74) | SLC6A9HSD17B2CA1CA2CA9 | |
| Org-25935 SCHEMBL7703028 | 0.87 | SLC6A9 (0.85) | SLC6A9CA1CA2CA9CA14 | |
| Org-25935 SCHEMBL7704305 | 0.87 | SLC6A9 (0.85) | SLC6A9CA1CA2CA9CA14 | |
| Lithium Ion SCHEMBL7704515 | 0.86 | SLC6A9 (0.60) | SLC6A9HSD17B2CA1CA2RORC | |
| Lithium Ion SCHEMBL7705019 | 0.81 | SLC6A9 (0.56) | SLC6A9CA1CA2CA9CA14 | |
| Lithium Ion SCHEMBL7698371 | 0.80 | SLC6A9 (0.53) | SLC6A9MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7698462 | 0.79 | SLC6A9 (0.69) | SLC6A9PPARDMTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7706983 | 0.79 | SLC6A9 (0.71) | SLC6A9TAS2R14NQO2MTNR1AMTNR1B | |
| Org-25935 SCHEMBL7703430 | 0.78 | SLC6A9 (1.00) | SLC6A9CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |