Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.69 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7703313 | 0.94 | SLC6A9 (0.74) | SLC6A9CA1CA2CA9CA14 | |
| Lithium Ion SCHEMBL7705019 | 0.91 | SLC6A9 (0.56) | SLC6A9CA1CA2CA9CA14 | |
| Lithium Ion SCHEMBL7706192 | 0.91 | SLC6A9 (0.64) | SLC6A9CA1CA2CA9CA14 | |
| Org-25935 SCHEMBL7704305 | 0.90 | SLC6A9 (0.85) | SLC6A9CA1CA2CA9CA14 | |
| Org-25935 SCHEMBL7703028 | 0.90 | SLC6A9 (0.85) | SLC6A9CA1CA2CA9CA14 | |
| Lithium Ion SCHEMBL7698371 | 0.90 | SLC6A9 (0.53) | SLC6A9HTR6ESR1NPC1RAB9A | |
| Lithium Ion SCHEMBL7704515 | 0.90 | SLC6A9 (0.60) | SLC6A9CA1CA2HSD17B2HTR6 | |
| Lithium Ion SCHEMBL7702956 | 0.85 | SLC6A9 (0.49) | SLC6A9HTR6 | |
| Lithium Ion SCHEMBL7703444 | 0.84 | SLC6A9 (0.62) | SLC6A9HTR6MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7704198 | 0.84 | SLC6A9 (0.51) | SLC6A9MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |