Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242970 | 0.85 | TBXAS1 (0.36) | CYP11B1CYP11B2TBXAS1NAMPTCYP19A1 | |
| SCHEMBL7242964 | 0.85 | TBXAS1 (0.36) | CYP11B1CYP11B2TBXAS1NAMPTCYP19A1 | |
| SCHEMBL7241573 | 0.80 | TBXAS1 (0.47) | TBXAS1CYP19A1 | |
| SCHEMBL7241571 | 0.80 | TBXAS1 (0.47) | TBXAS1CYP19A1 | |
| SCHEMBL7241553 | 0.80 | KDM4E (0.43) | TBXAS1KDM4ENPC1LMNARAB9A | |
| SCHEMBL7241558 | 0.80 | KDM4E (0.43) | TBXAS1KDM4ENPC1LMNARAB9A | |
| SCHEMBL8199405 | 0.78 | NTRK1 (0.36) | KDM4EMEN1KMT2A | |
| SCHEMBL7711906 | 0.75 | KDM4E (0.38) | KDM4ENPC1RAB9ANAMPTCYP19A1 | |
| SCHEMBL7247057 | 0.75 | KDM4E (0.38) | CYP11B1CYP11B2TBXAS1KDM4ENAMPT | |
| SCHEMBL7247059 | 0.75 | KDM4E (0.38) | CYP11B1CYP11B2TBXAS1KDM4ENAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |