Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5893993 | 1.00 | TGM2 (0.45) | TGM2PIM1PIM3PIM2CCNB2 | |
| SCHEMBL5893997 | 1.00 | TGM2 (0.45) | TGM2PIM1PIM3PIM2CCNB2 | |
| SCHEMBL4987422 | 0.86 | ALDH1A1 (0.49) | TGM2CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL4987427 | 0.86 | ALDH1A1 (0.49) | TGM2CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL5167993 | 0.84 | MAOA (0.46) | PIM1KDRNTRK1PRKAA1ALDH1A1 | |
| SCHEMBL5426677 | 0.84 | MAOA (0.46) | PIM1KDRNTRK1PRKAA1ALDH1A1 | |
| SCHEMBL5422752 | 0.81 | TGM2 (0.43) | TGM2PIM1PIM3PIM2CCNB2 | |
| SCHEMBL5422747 | 0.81 | TGM2 (0.43) | TGM2PIM1PIM3PIM2CCNB2 | |
| SCHEMBL5873845 | 0.81 | TGM2 (0.43) | TGM2PIM1PIM3PIM2CCNB2 | |
| SCHEMBL7706680 | 0.80 | RET (0.42) | PIM1KDRNTRK1PRKAA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |