Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700536 | 0.88 | GRM5 (0.36) | GRM5ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL7147535 | 0.86 | GRM5 (0.40) | GRM5ALDH1A1MAPTNPSR1HTT | |
| SCHEMBL7145867 | 0.83 | WDR5 (0.44) | GRM5ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL7140578 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL7703083 | 0.82 | ALDH1A1 (0.33) | ALDH1A1MAPTNPSR1HTTMAPK1 | |
| SCHEMBL7139831 | 0.81 | GRM5 (0.39) | GRM5ALDH1A1MAPTNPSR1HTT | |
| SCHEMBL7142627 | 0.80 | GRM5 (0.38) | GRM5ALDH1A1MAPTNPSR1HTT | |
| SCHEMBL7145991 | 0.79 | ALDH1A1 (0.44) | GRM5ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL7140140 | 0.78 | MAPT (0.43) | ALDH1A1MAPTHTTMAPK1NPC1 | |
| SCHEMBL7142921 | 0.77 | NPC1 (0.39) | ALDH1A1MAPTHTTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |