Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145848 | 0.83 | ALDH1A1 (0.36) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7142183 | 0.82 | MAPT (0.38) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7703657 | 0.82 | GRM5 (0.34) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7146607 | 0.81 | MAPT (0.44) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7143246 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2GAAMAPK1 | |
| SCHEMBL7143311 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBMAPK1MEN1 | |
| SCHEMBL7148612 | 0.78 | MAPK1 (0.37) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7139645 | 0.77 | MAPT (0.43) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7148217 | 0.77 | WDR5 (0.37) | ALDH1A1MAPTNPSR1SMN1; SMN2POLB | |
| SCHEMBL7142608 | 0.76 | MAPT (0.35) | ALDH1A1MAPTNPSR1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |