Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 11/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703659 | 0.87 | UCHL1 (0.36) | VCPCCR3UCHL1USP30HCRTR1 | |
| SCHEMBL7145195 | 0.79 | KDM4D (0.34) | CCR3 | |
| SCHEMBL7698442 | 0.78 | CCR3 (0.36) | VCPCCR3HCRTR1 | |
| SCHEMBL7699418 | 0.76 | CCR3 (0.34) | CCR3 | |
| SCHEMBL7703166 | 0.74 | VCP (0.34) | VCPCCR3UCHL1USP30HCRTR1 | |
| SCHEMBL7698696 | 0.74 | VCP (0.41) | VCPCCR3 | |
| SCHEMBL7702841 | 0.73 | VCP (0.42) | VCP | |
| SCHEMBL7141841 | 0.73 | KDM4D (0.35) | CCR3 | |
| SCHEMBL7703096 | 0.71 | VCP (0.42) | VCP | |
| SCHEMBL7143444 | 0.71 | KDM4D (0.35) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |