SCHEMBL7703829

SCHEMBL7703829

O=C1c2cccc3c(Br)ccc(c23)C(=O)N1O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.65
MAPT P10636 3/20 0.65
ERCC1 P07992 2/20 0.65
FEN1 P39748 2/20 0.65
ERCC4 Q92889 2/20 0.65
CYP1A2 P05177 1/20 0.65
TSHR P16473 1/20 0.65
ALOX12 P18054 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
CYP1B1 Q16678 14/20 0.64
ALDH1A1 P00352 3/20 0.59
KMT2A Q03164 3/20 0.59
KDM4E B2RXH2 2/20 0.59
LMNA P02545 2/20 0.59
PABPC1 P11940 2/20 0.59
XBP1 P17861 1/20 0.59
NFKB1 P19838 1/20 0.59
HTT P42858 1/20 0.59
SMARCA2 P51531 1/20 0.59
NFKB2 Q00653 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4866412 0.82 CYP1B1 (0.69) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL30905987 0.82 CYP1B1 (0.69) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL29074524 0.82 CYP1B1 (0.64) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL10261574 0.81 CYP1B1 (0.77) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL77179 0.81 CYP1B1 (0.61) POLBMAPTCYP1A2CYP1B1ALDH1A1
SCHEMBL29583035 0.81 CYP1B1 (0.61) POLBMAPTCYP1A2CYP1B1ALDH1A1
SCHEMBL30353799 0.79 CYP1B1 (0.68) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL29493708 0.79 CYP1B1 (0.68) POLBMAPTCYP1B1ALDH1A1KMT2A
SCHEMBL7709602 0.79 HKDC1 (0.59) POLBMAPTERCC1FEN1ERCC4
SCHEMBL29575259 0.79 CYP1B1 (0.60) POLBMAPTCYP1B1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362181-B1 BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS WARNER-LAMBERT COMPANY 2002-03-26 US claimed
EP-0939754-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1999-09-08 EP claimed
WO-1998019648-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6362181-B1 BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS WARNER-LAMBERT COMPANY 2002-03-26 US disclosed
US-6177423-B1 N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS WARNER-LAMBERT COMPANY 2001-01-23 US disclosed