Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149260 | 0.89 | RORC (0.37) | FFAR1GSK3BGRM5MEN1KMT2A | |
| SCHEMBL7703990 | 0.84 | GSK3B (0.41) | FFAR1GSK3BGRM5MEN1KMT2A | |
| SCHEMBL6612119 | 0.81 | GSK3B (0.40) | GSK3BGRM5MEN1KMT2ARAB9A | |
| SCHEMBL7706579 | 0.80 | PTGDR2 (0.42) | FFAR1PTGDR2TRPM4 | |
| SCHEMBL7141229 | 0.80 | HTT (0.37) | GSK3BMEN1KMT2AHDAC3VNN1 | |
| SCHEMBL7142666 | 0.80 | PTGDR2 (0.36) | GSK3BMEN1KMT2APTGDR2VNN1 | |
| SCHEMBL7146923 | 0.79 | SLC16A3 (0.36) | MEN1KMT2AHDAC3 | |
| SCHEMBL7701365 | 0.79 | HTT (0.40) | GRM5MEN1KMT2ARAB9A | |
| SCHEMBL7142827 | 0.79 | KMT2A (0.43) | GSK3BMEN1KMT2ARAB9A | |
| SCHEMBL7704027 | 0.78 | FFAR1 (0.49) | FFAR1MEN1KMT2APTGDR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |