Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138333 | 0.87 | FFAR1 (0.44) | FFAR1PTGDR2 | |
| SCHEMBL7698583 | 0.83 | FFAR1 (0.43) | FFAR1PTGDR2NPC1CYP2C9MEN1 | |
| SCHEMBL15459105 | 0.78 | FFAR1 (0.52) | FFAR1PTGDR2KDM4EALDH1A1NPC1 | |
| SCHEMBL7704399 | 0.78 | FFAR1 (0.40) | FFAR1PTGDR2MEN1KMT2ALMNA | |
| SCHEMBL7701331 | 0.76 | PTGDR2 (0.34) | FFAR1PTGDR2ALDH1A1GAA | |
| SCHEMBL7699272 | 0.74 | GAA (0.39) | FFAR1KDM4EALDH1A1NPC1CYP2C9 | |
| SCHEMBL29608299 | 0.73 | FFAR1 (0.67) | FFAR1PTGDR2KDM4EALDH1A1NPC1 | |
| SCHEMBL7141263 | 0.72 | PTGDR2 (0.41) | FFAR1PTGDR2CYP2C9MAPTHPGD | |
| SCHEMBL7142632 | 0.72 | VCP (0.39) | PTGDR2KDM4EHPGDHTT | |
| SCHEMBL7142218 | 0.72 | VCP (0.40) | PTGDR2KDM4EHPGDKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |