Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18364556 | 0.90 | LMNA (0.40) | ALDH1A1KDM4ELMNAL3MBTL1TDP1 | |
| SCHEMBL6901385 | 0.87 | LMNA (0.46) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL18374938 | 0.82 | LMNA (0.52) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL17124206 | 0.77 | LMNA (0.49) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL13812603 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL5247063 | 0.76 | L3MBTL1 (0.40) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL4180647 | 0.75 | LMNA (0.48) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL12180442 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4ELMNAL3MBTL1HPGD | |
| SCHEMBL31562598 | 0.74 | POLB (0.47) | KDM4EL3MBTL1GAATSHRMEN1 | |
| SCHEMBL31562332 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | disclosed |
| EP-0818431-A1 | Scavenger assisted combinatorial process for preparing libaries of secondary amine compounds | ELI LILLY AND COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0816310-A2 | Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |