Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 2/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738981 | 0.80 | RHEB (0.41) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL14738857 | 0.77 | OPRL1 (0.38) | GSK3BGSK3ARHEBOPRL1ALDH1A1 | |
| SCHEMBL7713894 | 0.77 | DRD4 (0.44) | RHEBOPRL1OPRM1OPRK1CYP1A2 | |
| SCHEMBL7705194 | 0.76 | RHEB (0.39) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7706342 | 0.75 | RHEB (0.38) | GSK3BRHEBALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7707749 | 0.75 | ALDH1A1 (0.42) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL14753481 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7705773 | 0.74 | ALDH1A1 (0.44) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7712729 | 0.74 | PDK2 (0.37) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL14738973 | 0.74 | PDK2 (0.37) | RHEBALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102917707-A | Azaindole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME | 2013-02-06 | — | — | CN | claimed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| WO-2011140164-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | CCNB2 2304/4885CDK1 1779/4885CCNB1 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.