Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 6/20 | 1.00 |
| ▸ | HCRTR1 | O43613 | 5/20 | 1.00 |
| ▸ | TSPO | P30536 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707208 | 0.90 | HCRTR2 (0.81) | HCRTR2HCRTR1TSPOLMNAMAPT | |
| SCHEMBL7702650 | 0.88 | HCRTR2 (0.78) | HCRTR2HCRTR1TSPOALDH1A1KDM4E | |
| SCHEMBL7708626 | 0.83 | HCRTR1 (0.71) | HCRTR2HCRTR1ALDH1A1KDM4ELMNA | |
| SCHEMBL7708409 | 0.81 | HCRTR1 (0.68) | HCRTR2HCRTR1ALDH1A1KDM4ELMNA | |
| SCHEMBL7712431 | 0.80 | HCRTR2 (0.66) | HCRTR2HCRTR1TSPOLMNAMAPT | |
| SCHEMBL7709772 | 0.76 | HCRTR1 (1.00) | HCRTR2HCRTR1TSPOALDH1A1KDM4E | |
| SCHEMBL7713631 | 0.76 | HCRTR2 (0.61) | HCRTR2HCRTR1TSPOALDH1A1LMNA | |
| SCHEMBL7703519 | 0.74 | HCRTR2 (0.58) | HCRTR2HCRTR1TSPOALDH1A1LMNA | |
| SCHEMBL7703516 | 0.72 | HCRTR1 (0.90) | HCRTR2HCRTR1TSPOALDH1A1KDM4E | |
| SCHEMBL7703511 | 0.72 | HCRTR1 (0.90) | HCRTR2HCRTR1TSPOALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |