Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.71 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713640 | 0.85 | HCRTR2 (0.54) | HCRTR1HCRTR2HSD17B10TSHRPTGDR2 | |
| SCHEMBL7708409 | 0.84 | HCRTR1 (0.68) | HCRTR1HCRTR2TSHRKDM4EMEN1 | |
| SCHEMBL7704867 | 0.83 | HCRTR2 (1.00) | HCRTR1HCRTR2KDM4EALDH1A1LMNA | |
| SCHEMBL7707104 | 0.78 | HCRTR1 (0.47) | HCRTR1HCRTR2HSD17B10PTGDR2LMNA | |
| SCHEMBL2588933 | 0.76 | HCRTR2 (0.56) | HCRTR1HCRTR2HSD17B10TSHRKDM4E | |
| SCHEMBL29092151 | 0.76 | HCRTR1 (0.56) | HCRTR1HCRTR2HSD17B10KDM4EMEN1 | |
| SCHEMBL2592911 | 0.74 | HCRTR2 (0.54) | HCRTR1HCRTR2HSD17B10TSHRKDM4E | |
| SCHEMBL2595050 | 0.74 | HCRTR2 (0.53) | HCRTR1HCRTR2PTGDR2KDM4EMEN1 | |
| SCHEMBL3905353 | 0.73 | HSD17B10 (0.67) | HSD17B10TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL14631512 | 0.73 | HSD17B10 (0.67) | HSD17B10TSHRKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |