Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 5/20 | 0.81 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 5/20 | 0.46 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712431 | 0.90 | HCRTR2 (0.66) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7704867 | 0.90 | HCRTR2 (1.00) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7713631 | 0.87 | HCRTR2 (0.61) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7703519 | 0.85 | HCRTR2 (0.58) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7702650 | 0.81 | HCRTR2 (0.78) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7702437 | 0.80 | HCRTR1 (0.81) | HCRTR2HCRTR1POLBLMNAMAPT | |
| SCHEMBL7708626 | 0.77 | HCRTR1 (0.71) | HCRTR2HCRTR1POLBLMNAMAPT | |
| SCHEMBL7708524 | 0.76 | HCRTR2 (0.74) | HCRTR2HCRTR1POLBLMNATSPO | |
| SCHEMBL7708409 | 0.74 | HCRTR1 (0.68) | HCRTR2HCRTR1LMNA | |
| SCHEMBL7707649 | 0.70 | HCRTR2 (0.82) | HCRTR2HCRTR1POLBLMNATSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |