Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426839 | 0.88 | MEN1 (0.53) | ALDH1A1LMNASMN1; SMN2POLBMAPK1 | |
| SCHEMBL3480113 | 0.88 | MAPK9 (0.54) | ALDH1A1LMNASMN1; SMN2POLBMAPK1 | |
| SCHEMBL3480648 | 0.88 | MAPK9 (0.60) | ALDH1A1LMNASMN1; SMN2MAPK1MAPK9 | |
| SCHEMBL2421342 | 0.86 | MAPK9 (0.56) | ALDH1A1LMNASMN1; SMN2POLBMAPK1 | |
| SCHEMBL2426378 | 0.85 | MAPK9 (0.53) | ALDH1A1LMNASMN1; SMN2POLBTSHR | |
| SCHEMBL7434542 | 0.84 | DRD2 (0.58) | LMNASMN1; SMN2POLBMAPK1TSHR | |
| SCHEMBL7894066 | 0.83 | MAPK9 (0.51) | ALDH1A1SMN1; SMN2POLBTSHRMAPK9 | |
| SCHEMBL6431959 | 0.83 | MAPK9 (0.55) | ALDH1A1LMNASMN1; SMN2MAPK1MAPK9 | |
| SCHEMBL2421105 | 0.82 | MAPK9 (0.53) | ALDH1A1LMNAPOLBTSHRMAPK9 | |
| SCHEMBL7439629 | 0.81 | MAPK9 (0.51) | ALDH1A1LMNASMN1; SMN2MAPK1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193268-A1 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases | Applied Research Systems ARS Holding N.V. (AN) | 2002-04-03 | — | — | EP | claimed |
| EP-1193268-A1 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases | Applied Research Systems ARS Holding N.V. (AN) | 2002-04-03 | — | — | EP | disclosed |