Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.37 |
| ▸ | PRCP | P42785 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700053 | 0.87 | TRPM8 (0.35) | TRPM8PRCPHHATCHRM3HDAC1 | |
| SCHEMBL7702996 | 0.86 | TRPM8 (0.39) | TRPM8PRCPKCNH2HHATCHRM3 | |
| SCHEMBL7700015 | 0.84 | TRPM8 (0.39) | TRPM8PRCPHHATCHRM3HDAC1 | |
| SCHEMBL7701032 | 0.84 | HPGD (0.37) | TRPM8PRCPCHRM3 | |
| SCHEMBL7697839 | 0.83 | PRCP (0.43) | TRPM8PRCPKCNH2HHATCHRM3 | |
| SCHEMBL7701159 | 0.83 | TRPM8 (0.39) | TRPM8PRCPHHATCHRM3HDAC1 | |
| SCHEMBL7702539 | 0.79 | PRCP (0.46) | TRPM8PRCPHHATCHRM3HDAC1 | |
| SCHEMBL7701133 | 0.79 | PRCP (0.54) | PRCPKCNH2HHATCHRM3HDAC1 | |
| SCHEMBL7699769 | 0.79 | PRCP (0.37) | TRPM8PRCPKCNH2HHATCHRM3 | |
| SCHEMBL7705909 | 0.79 | CYP19A1 (0.44) | TRPM8PRCPHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |