Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713466 | 0.98 | MEN1 (0.40) | MEN1KMT2APPARAMAPTKDM4E | |
| SCHEMBL7000166 | 0.87 | ALDH1A1 (0.42) | MEN1KMT2AMAPTKDM4ENLRP3 | |
| SCHEMBL6994414 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL7704908 | 0.78 | ALDH1A1 (0.39) | MEN1KMT2APPARAMAPTNLRP3 | |
| SCHEMBL9163910 | 0.78 | MAPT (0.40) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL7710377 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2AMAPTKDM4ENLRP3 | |
| SCHEMBL10682873 | 0.75 | MAPT (0.35) | MEN1KMT2APPARAMAPTKDM4E | |
| SCHEMBL7708269 | 0.75 | ALDH1A1 (0.39) | MEN1KMT2APPARAMAPTKDM4E | |
| SCHEMBL9165831 | 0.75 | PDK1 (0.37) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL6999622 | 0.73 | ALDH1A1 (0.38) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |