Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPRG | P23470 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28588131 | 0.88 | TAS2R14 (0.55) | RIPK1TAS2R14CTSLNR3C1 | |
| SCHEMBL7707821 | 0.85 | AKT1 (0.48) | RIPK1CTSL | |
| SCHEMBL6338886 | 0.84 | TAS2R14 (0.42) | TAS2R14TSHR | |
| SCHEMBL21987970 | 0.80 | RIPK1 (0.51) | RIPK1CTSLAOC3TSHRRECQL | |
| SCHEMBL7705917 | 0.77 | TAS2R14 (0.44) | TAS2R14NR3C1 | |
| SCHEMBL7705112 | 0.77 | STAT5B (0.46) | TAS2R14 | |
| SCHEMBL2262829 | 0.76 | RIPK1 (0.47) | RIPK1CTSLAOC3TSHRRECQL | |
| SCHEMBL1965890 | 0.76 | RIPK1 (0.47) | RIPK1TAS2R14CTSLAOC3TSHR | |
| SCHEMBL7705341 | 0.76 | TSHR (0.40) | TSHRRECQL | |
| SCHEMBL7702197 | 0.76 | RIPK1 (0.43) | RIPK1TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355665-B1 | ANTIHISTAMINES, ANTIALLERGENS AND IRRITABLE BOWEL SYNDROME. | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-03-12 | — | — | US | disclosed |
| WO-1999005114-A2 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |