Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.41 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705112 | 0.87 | STAT5B (0.46) | TAS2R14 | |
| SCHEMBL7707821 | 0.87 | AKT1 (0.48) | RIPK1 | |
| SCHEMBL7707801 | 0.86 | KMT2A (0.43) | HDAC6 | |
| SCHEMBL7705341 | 0.86 | TSHR (0.40) | — | |
| SCHEMBL6338886 | 0.86 | TAS2R14 (0.42) | TAS2R14NR1D1PTGER2 | |
| SCHEMBL5708152 | 0.82 | TAS2R14 (0.58) | TAS2R14 | |
| SCHEMBL7430459 | 0.79 | RIPK1 (0.59) | RIPK1KDM1AHDAC8HDAC6NR1D1 | |
| SCHEMBL30027626 | 0.79 | TSHR (0.39) | TAS2R14PTGER2 | |
| SCHEMBL17553442 | 0.78 | RIPK1 (0.47) | RIPK1KDM1AHDAC8HDAC6NR1D1 | |
| SCHEMBL2897902 | 0.77 | HDAC3 (0.46) | RIPK1KDM1AHDAC8HDAC6NR1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355665-B1 | ANTIHISTAMINES, ANTIALLERGENS AND IRRITABLE BOWEL SYNDROME. | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-03-12 | — | — | US | disclosed |
| WO-1999005114-A2 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |