Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 11/20 | 0.53 |
| ▸ | ESR1 | P03372 | 10/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050136 | 0.88 | ESR1 (0.50) | ESR2ESR1LTA4HMEN1KMT2A | |
| SCHEMBL30494152 | 0.88 | ESR1 (0.60) | ESR2ESR1XDH | |
| SCHEMBL3111436 | 0.88 | ESR1 (0.60) | ESR2ESR1XDH | |
| SCHEMBL7934940 | 0.86 | SMN1; SMN2 (0.45) | ESR2ESR1MEN1KMT2ANPC1 | |
| SCHEMBL8501462 | 0.86 | ESR1 (0.47) | ESR2ESR1XDHMEN1KMT2A | |
| SCHEMBL4966110 | 0.86 | MGAM (0.53) | ESR2ESR1NOD2MAPTMAPK1 | |
| SCHEMBL8501466 | 0.85 | AKR1C3 (0.55) | ESR2ESR1MAPTTSHRCYP3A4 | |
| SCHEMBL7187874 | 0.84 | ESR1 (0.55) | ESR2ESR1NPC1RAB9ATP53 | |
| SCHEMBL1359376 | 0.84 | ESR1 (0.59) | ESR2ESR1MIFMAPK1KDM4E | |
| SCHEMBL7189743 | 0.83 | ALDH1A1 (0.49) | ESR2ESR1MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355632-B1 | AROMATIC ETHER AMINES FOR TREATMENT OF OSTEOPOROSIS | ELI LILLY AND COMPANY | 2002-03-12 | — | — | US | disclosed |
| US-6268361-B1 | ESTROGEN DEPENDENT DISORDERS INCLUDING CANCER, ENODMETRIOSIS, ETC | PALKOWITZ ALAN D (US) | 2001-07-31 | — | — | US | disclosed |
| US-5998401-A | POSTMENOPAUSE THERAPY | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0729951-B1 | Naphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5574190-A | AROMATIC ETHER DERIVATIVES FOR TREATMENT OF HORMONE DEPENDENT CANCER SUCH AS BREAST CANCER | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5567712-A | THERAPY FOR ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0729951-A1 | Naphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |