Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182654 | 0.93 | ALOX5 (0.43) | ALDH1A1CYP2A6GSTP1ESR1MAPT | |
| SCHEMBL7191254 | 0.93 | ESR1 (0.44) | ALDH1A1CYP2A6GSTP1ESR1ESR2 | |
| SCHEMBL3120120 | 0.91 | CYP1A2 (0.44) | ALDH1A1CYP2A6GSTP1ESR1ESR2 | |
| SCHEMBL7189972 | 0.89 | MAPT (0.44) | ALDH1A1CYP2A6GSTP1CYP1A2PLAU | |
| SCHEMBL6050146 | 0.89 | GSTP1 (0.43) | ALDH1A1CYP2A6GSTP1ESR1ESR2 | |
| SCHEMBL7187373 | 0.87 | ALDH1A1 (0.49) | ALDH1A1CYP2A6ESR1ESR2SMN1; SMN2 | |
| SCHEMBL7190071 | 0.86 | GSTP1 (0.39) | ALDH1A1CYP2A6GSTP1CYP1A2SLC2A1 | |
| SCHEMBL7194282 | 0.86 | ERN1 (0.39) | ALDH1A1CYP2A6GSTP1ESR1ESR2 | |
| SCHEMBL7188354 | 0.85 | RELA (0.42) | ALDH1A1CYP2A6GSTP1ESR1ESR2 | |
| SCHEMBL1359561 | 0.85 | ESR1 (0.47) | ALDH1A1CYP2A6GSTP1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6355632-B1 | AROMATIC ETHER AMINES FOR TREATMENT OF OSTEOPOROSIS | ELI LILLY AND COMPANY | 2002-03-12 | — | — | US | disclosed |
| US-6268361-B1 | ESTROGEN DEPENDENT DISORDERS INCLUDING CANCER, ENODMETRIOSIS, ETC | PALKOWITZ ALAN D (US) | 2001-07-31 | — | — | US | disclosed |
| US-5998401-A | POSTMENOPAUSE THERAPY | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0729951-B1 | Naphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5574190-A | AROMATIC ETHER DERIVATIVES FOR TREATMENT OF HORMONE DEPENDENT CANCER SUCH AS BREAST CANCER | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5567712-A | THERAPY FOR ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0729951-A1 | Naphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |