Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497579 | 0.94 | SMN1; SMN2 (0.42) | ESR1ESR2BACE1KDM4ETP53 | |
| SCHEMBL8497550 | 0.94 | ESR1 (0.49) | ESR1ESR2BACE1KDM4EMEN1 | |
| SCHEMBL8499778 | 0.92 | ESR1 (0.54) | ESR1ESR2MAPTKMT2A | |
| SCHEMBL8501430 | 0.90 | ESR1 (0.46) | ESR1ESR2KDM4EALDH1A1MAPT | |
| SCHEMBL8501243 | 0.90 | KDM4E (0.39) | ESR1ESR2KDM4EMEN1ALDH1A1 | |
| SCHEMBL8497702 | 0.89 | ESR1 (0.49) | ESR1ESR2MEN1CYP3A4CYP2D6 | |
| SCHEMBL8500568 | 0.88 | ESR1 (0.48) | ESR1ESR2MEN1KMT2A | |
| SCHEMBL8502205 | 0.87 | MTNR1A (0.43) | ESR1ESR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8497879 | 0.87 | KMT2A (0.42) | ESR1ESR2BACE1KDM4EALDH1A1 | |
| SCHEMBL8497867 | 0.86 | ESR1 (0.57) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |