Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 10/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705507 | 0.85 | PDE10A (0.51) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL7711514 | 0.84 | MTNR1A (0.45) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL7703632 | 0.74 | PDE10A (0.59) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL8272339 | 0.73 | MAOA (0.50) | CYP19A1CYP11B1CYP11B2PDE4BLMNA | |
| SCHEMBL8271346 | 0.73 | PDE4B (0.41) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL8272330 | 0.73 | PDE4B (0.41) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL5018006 | 0.73 | CYP19A1 (0.49) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL2559533 | 0.72 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL2556256 | 0.72 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7704619 | 0.72 | PDE4A (0.48) | CYP19A1CYP11B1CYP11B2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |