SCHEMBL77056

SCHEMBL77056

Cc1cccc(C(F)(F)F)c1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.50
MPL P40238 2/20 0.39
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
PARP1 P09874 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
POLB P06746 2/20 0.38
ALDH1A1 P00352 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HSD11B1 P28845 2/20 0.37
TSHR P16473 3/20 0.37
CYP3A4 P08684 2/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
SCN8A Q9UQD0 1/20 0.36
P2RX7 Q99572 1/20 0.36
AR P10275 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29512913 1.00 CD44 (0.50) CD44MPLGABRA1GABRB2PARP1
SCHEMBL23591999 0.84 CD44 (0.48) CD44MPLGABRA1GABRB2PARP1
SCHEMBL396026 0.83 POLB (0.44) MPLTDP1POLBALDH1A1L3MBTL1
SCHEMBL5958679 0.83 CD44 (0.46) CD44MPLGABRA1GABRB2PARP1
SCHEMBL5958756 0.83 CD44 (0.46) CD44MPLGABRA1GABRB2PARP1
SCHEMBL5847428 0.81 CD44 (0.45) CD44MPLGABRA1GABRB2PARP1
SCHEMBL30154643 0.79 GABRA1 (0.56) CD44GABRA1GABRB2TDP1POLB
SCHEMBL1804107 0.79 GABRA1 (0.56) CD44GABRA1GABRB2TDP1POLB
SCHEMBL14553799 0.79 POLB (0.41) CD44TDP1POLBALDH1A1TSHR
SCHEMBL5958686 0.78 CD44 (0.42) CD44GABRA1GABRB2TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0185128-B1 CATALYTIC HYDRODESULFURIZATION OF ORTHO-AMINOBENZYL SULFIDES Monsanto Company (US) 1990-05-16 EP claimed
US-4806687-A Catalytic hydrodesulfurization of ortho-aminobenzylsulfides MONSANTO COMPANY (US) 1989-02-21 US claimed
EP-0185128-A1 Catalytic hydrodesulfurization of ortho-aminobenzyl sulfides Monsanto Company (US) 1986-06-25 EP claimed
US-4578514-A Synthesis of sulfilimines MONSANTO COMPANY (US) 1986-03-25 US claimed
US-4404069-A Electrolytic desulfurization of anilino sulfur compounds MONSANTO COMPANY (US) 1983-09-13 US claimed
JP-2045451-A None JP disclosed
JP-63270632-A None JP disclosed
JP-63270631-A None JP disclosed
EP-4724436-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2026-04-15 EP disclosed
EP-4642767-A1 PYRIMIDINE CARBOXAMIDE COMPOUNDS Acrivon Therapeutics, Inc. (US) 2025-11-05 EP disclosed
WO-2024259017-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-12-19 WO disclosed
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 US disclosed
US-4203920-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4147804-A ANTIARRHYTHMIA AGENTS WILLIAM H. RORER, INC. (US) 1979-04-03 US disclosed
US-4132737-A ENZYME INHIBITORS ELI LILLY AND COMPANY (US) 1979-01-02 US disclosed
US-4060635-A Amidinoureas for treating diarrhea WILLIAM H. RORER, INC. (US) 1977-11-29 US disclosed
US-4046554-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1977-09-06 US disclosed
US-3966811-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP CD44 3283/4885MPL 4002/4885GABRA1 2431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.