Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | GAA | P10253 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 8/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21063806 | 0.85 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL14548357 | 0.84 | RAB9A (0.68) | ALDH1A1GAAHSD17B10RAB9ANPC1 | |
| SCHEMBL6358306 | 0.83 | ALDH1A1 (0.66) | ALDH1A1GAAHSD17B10RAB9ANPC1 | |
| SCHEMBL12319476 | 0.83 | ALDH1A1 (0.66) | ALDH1A1GAAHSD17B10RAB9ANPC1 | |
| SCHEMBL6359372 | 0.81 | SMN1; SMN2 (0.72) | ALDH1A1GAAHSD17B10RAB9ANPC1 | |
| SCHEMBL18773997 | 0.80 | NPC1 (1.00) | ALDH1A1GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15676745 | 0.80 | RAB9A (0.74) | ALDH1A1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL6842122 | 0.80 | HDAC2 (0.80) | ALDH1A1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL13753335 | 0.80 | ALDH1A1 (0.69) | ALDH1A1GAAHSD17B10RAB9ANPC1 | |
| SCHEMBL19072052 | 0.80 | ALDH1A1 (0.61) | ALDH1A1GAAHSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |